Carbon Tetrachloride-induced Hepatotoxicity in Rats - Protective Role of Aqueous Leaf Extracts of Coccinia Grandis
نویسندگان
چکیده
The present study was conducted to evaluate the hepatoprotective effects of an aqueous leaf extract of Coccinia grandis on carbon tetrachloride (CCl4) induced liver damage in albino rats. Wistar albino rats weighing around 180-200g were used. Toxicity was induced by using 30% CCl4 suspended in olive oil (1.0 ml/kg body wt intraperitoneal) after every 72 hrs for 3doses. The aqueous leaf extract at a dose of 250mg/kg was administered orally by intragastric tube for 10 days. Blood and liver tissue were collected for the assessment of serum marker enzymes such as ALT, AST and ALP. The liver tissue was used for histopathological assessment.
منابع مشابه
Protective Effect of Coccinia Indica Leaf Extract against Alcohol Combined with Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats
Liver is a major metabolic organ affected by various toxins and chemicals. So the potential therapeutic agent is needed for the treatment of liver diseases. Natural products are the best source of remedies for the treatment of all diseases.The aim of our study was to investigate the effect of leaf extract of Coccinia indica against Alcohol combines with CCl4 and Paracetamol induced hepatotoxici...
متن کاملProtective Effect of N-Acetyl Cysteine in Carbon Tetrachloride-Induced Hepatotoxicity in Rats
The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...
متن کاملThe Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Rats
Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous ...
متن کاملProtective Effect of Ricinus communis Leaves Extract on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats
Ricinus communis Linn. (Euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. In the Indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a lo...
متن کاملProtective Effect of Berberis integerrima Fruit Extract on Carbon-Tetrachloride Induced Hepatotoxicity in Rats
Background & Objective: Hepatoprotective effect of antioxidants such as flavnoids has been demonstrated. The aim of the present study was to assess the hepatoprotective effect of the methanolic extract of Berberis integerrima fruit (MEBIF) on carbon-tetrachloride (CCL4) induced hepatotoxicity in rats. Materials & Methods: Forty male rats were divided into 5 groups as follows: 1) normal, 2) toxi...
متن کامل